This experimentally intensive course builds on the skills obtained in the second year program and is designed for third and fourth year students with interest in property-directed chemical research. Students will develop competencies in advanced synthetic techniques and instrumentation. These may include vacuum distillation, glovebox use, manipulating reactions under anhydrous inert conditions, microwave synthesis, column chromatography, UV-Vis, CV, NMR, and computational methods. Students cannot take CHY 40A/B and CHY 399 in the same term.