Introduction to basic physics and chemistry of radiation interactions, free radicals, oxidation and reduction. Subcellular and cellular effects: killing, repair, sensitization and protection. Measurement methods. Survival curves and their significance. Modification of the radiation response. Tissue effects, genetic and carcinogenic effects, mutations, hazards. Effects of heat on tissue. Thermal dosimetry. Biology of Thermal Potentiation of Radiotherapy. High temperature thermal therapy.